TitleMethodologyUtilityTurnaround TimePreferred Specimen(s)hf:tax:category
ADENOVIRUSImmunohistochemistryDetects adenovirus infections24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
ADIPOPHILINImmunohistochemistryIntracytoplasmic lipid in sebaceous tumors24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
AFBSpecial Histochemical StainDetects Mycobacterium TB and other acid-fast mycobacteria24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
ALCIAN BLUE 2.5Special Histochemical StainDetects acid mucins and mucopolysaccharides24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
ALIZARIN RED (CALCIUM)Special Histochemical StainStains calcium in tissue sections and in osteocytes24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
AMYLOID P PROTEINImmunohistochemistryUsed to subtype amyloid proteins and stains normal elastic tissue24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
ANDROGEN RECEPTORImmunohistochemistryDetected in breast cancer, prostate cancer, sebaceous carcinoma24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
APP (AMYLOID PRECURSOR PROTEIN)ImmunohistochemistryIdentifies neurofibrillary tangles in Alzheimers, and early changes of ischemic brain injury24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
BAP1ImmunohistochemistryLoss in BAP1 mutated nevi, uveal melanomas and mesothelioma24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
BCL-2ImmunohistochemistryUsed to identify lymphoma type and soft tissue tumors24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
BCL-6ImmunohistochemistryFollicle center cell marker24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
BETA-CATENINImmunohistochemistryUsed to identify fibromatosis and various tumors24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
BRAF V600EImmunohistochemistryIdentifies BRAF V600E mutations in melanoma, papllary thyroid carcinoma and colorectal carcinoma48 to 72 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
C-MYCImmunohistochemistryBurkitts lymphoma, a subset of other B-cell lymphomas24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
C4DImmunohistochemistryUsed for identification of complement deposition including in early myocardial infarction24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CALRETININImmunohistochemistryA marker of mesothelioma, adrenal cortical tumors, and sex cord stromal tumors24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
Carcinoembryonic antigen (CEA , MONOCLONAL)ImmunohistochemistryExpressed in adenocarcinomas of multiple primary sites24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD10ImmunohistochemistryUsed to phenotype lymphomas, positive in endometrial stromal tumors, renal cell carcinomas24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD117 (c-KIT)ImmunohistochemistryExpressed in mast cells, GI stromal tumors, tumor expression for targeted therapeutics24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD138 (Syndecan-1)ImmunohistochemistryA plasma cell marker; also stains some epithelial tumors.24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD15ImmunohistochemistryMyeloid cells, Hodgkin lymphoma, differentiation of mesothelioma vs. adenocarcinoma.24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD163ImmunohistochemistryA macrophage marker.24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD1AImmunohistochemistryIdentifies thymic T cells, thymoma, and Langerhans cells24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD20ImmunohistochemistryB cell marker in lymphoma/ leukemia typing24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD21ImmunohistochemistryStains follicular dendritic cells24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD23ImmunohistochemistryStains follicular dendritic cells and some follicular mantle zone B-lymphocytes24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD3Immunohistochemistrystains T cells in lymphoma/ leukemia typing24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD30ImmunohistochemistryLymphoma typing, including Hodgkin's, ALCL, lymphomatoid papulosis & embryonal carcinoma.24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD31ImmunohistochemistryMarker of vascular differentiation and positive in certain histiocytes24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD34ImmunohistochemistryMarker of vascular differentiation, hematopoietic progenitor cells, and specific soft tissue tumors.24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD4ImmunohistochemistryExpressed in helper T cells in lymphoma/ leukemia typing24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD43ImmunohistochemistryPositive in all T cells and NK cells, used in lymphoma/ leukemia typing24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD45, leukocyte common antigen (LCA)ImmunohistochemistryExpressed on all leukocytes24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD5ImmunohistochemistryStains T cells in lymphoma/ leukemia typing24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD56ImmunohistochemistryExpressed in NK cells, and a marker of neuroendocrine differentiation24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD57ImmunohistochemistryExpressed in NK cells, cytotoxic T cells, and a marker of neuroendocrine differentiation24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD63 (NKI/C3)ImmunohistochemistryUsed as a marker for neurothekeoma and melanoma24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD68ImmunohistochemistryA histiocytic/ monocytic marker24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD7ImmunohistochemistryExpressed in T cells, natural killer cells and precursors in lymphoma/ leukemia typing.24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD79aImmunohistochemistryA pan B-cell marker, including plasma cells24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CD8ImmunohistochemistryExpressed in cytotoxic T cells in lymphoma/ leukemia typing24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CDX2ImmunohistochemistryA marker of intestinal differentiation, useful for metastatic carcinoma of unknown primary24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CHROMAGRANIN AImmunohistochemistryExpressed in neuroendocrine tumors24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CK 19ImmunohistochemistryA prognostic marker in islet cell tumors which assists in identifying papillary thyroid carcinoma.24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CK 20ImmunohistochemistryUsed to identify metastatic carcinoma of an unknown primary.24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CK 5/6ImmunohistochemistryUsed to identify basal cells or myoepithelial cells in the breast and prostate.24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CK 7ImmunohistochemistryUsed to identify metastatic carcinoma of an unknown primary.24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CK 8/18ImmunohistochemistryUsed to identify most types of adenocarcinomas and some squamous cell carcinomas.24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CK HMW (34BE12)ImmunohistochemistryUsed to identify prostate basal cells and metastatic carcinoma of an unknown primary.24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
CMVImmunohistochemistryDetects cytomegalovirus infections24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
COLLOIDAL IRONSpecial Histochemical StainStains acid mucins and Cryptococcus neoformans24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
CONGO REDSpecial Histochemical StainStains amyloid fibrils in tissue24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
CRYSTAL VIOLETSpecial Histochemical StainStains amyloid24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
CYCLIN D1ImmunohistochemistryMantle cell lymphoma and for targeted tumor therapeutics24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
D2-40 (PODOPLANIN)ImmunohistochemistryA lymphatic vascular marker, mesothelioma, seminoma, dermatofibroma24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
DESMINImmunohistochemistryReactive in skeletal, cardiac, and smooth muscle24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
Epidermal growth factor receptor (EGFR)ImmunohistochemistryMalignant transformation of native squamous cells at various sites24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
Epithelial membrane antigen (EMA)ImmunohistochemistryExpressed in normal and neoplastic epithelia of various origin, subset of Hodgkin's24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
ERGImmunohistochemistryNuclear expression in endothelial cells24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
Estrogen receptor (ER)ImmunohistochemistryExpressed in breast cancer, expressed by mammry analogue carcinomas24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
FACTOR XIIIAImmunohistochemistryDermal dendritic cell marker, positive in dermatofibroma.24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
FITE (MODIFIED AFB)Special Histochemical StainStains atypical mycobacteria such as Mycobacterium leprae and Nocardia spp.24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
FLI-1ImmunohistochemistryPositive in Ewing’s sarcoma, vascular tumors24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
FONTANA MASSONSpecial Histochemical StainDetects melanin pigment, argentaffin granules, dematiaceous fungi24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
FOUCHETSpecial Histochemical StainStains bilirubin and collagen in tissue sections24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
GATA 3ImmunohistochemistryVarious cancers: breast, urothelial, chromophobe RCC, skin adnexal24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
GCDFP-15ImmunohistochemistryPositive in breast carcinomas, sweat gland carcinomas, salivary gland mammary analogue tumors.24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
GFAPImmunohistochemistryExpressed by glial tumors and some salivary gland tumors24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
GIEMSASpecial Histochemical StainMast cells, malaria, Trypanosoma, bacteria, Leishmania, Histoplasma, Toxoplasma24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
GLYCOPHORINImmunohistochemistryPositive in nucleated and mature erythrocytes24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
GMSSpecial Histochemical StainDetects fungal organisms24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
GRAMSpecial Histochemical StainIdentifies gram-positive and gram-negative bacteria24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
H-CALDESMONImmunohistochemistryMarker of smooth muscle differentiation24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
H. PYLORIImmunohistochemistryStains H. Pylori24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
HHV-8ImmunohistochemistryDetects HHV 8 in Kaposi's sarcoma, some cases of Castleman's, and some lymphomas24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
HMB45ImmunohistochemistryPositive in melanomas, angiomyolipoma, and other PEComas24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
HSV 1ImmunohistochemistryDetects Herpes Simplex Virus 124 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
HSV 2ImmunohistochemistryDetects Herpes Simplex Virus 224 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
KAPPACISHDetects kappa light chains24 to 48 Hours*Paraffin block or unstained sections on charged slidesish
KI-67ImmunohistochemistryA proliferation marker24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
LAMBDACISHDetects lambda light chains24 to 48 Hours*Paraffin block or unstained sections on charged slidesish
MAMMOGLOBINImmunohistochemistryMammary tissue/carcinoma, some salivary gland and sweat gland tumors24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
MELAN A/KI-67ImmunohistochemistryDual stain for quantification of proliferation in melanocytes24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
MELAN-AImmunohistochemistryA melancytic marker. Also positive in angiomyolipoma and other PEComas24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
MLH-1ImmunohistochemistryUsed to identify hereditary cancer syndromes and mismatch repair gene mutations24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
MSAImmunohistochemistryExpressed in skeletal and smooth muscle tumors24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
MSH-2ImmunohistochemistryUsed to identify hereditary cancer syndromes and mismatch repair gene mutations24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
MSH-6ImmunohistochemistryUsed to identify hereditary cancer syndromes and mismatch repair gene mutations24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
MUC4ImmunohistochemistryExpressed in low grade fibromyxoid sarcoma and various adenocarcinomas24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
MUCICARMINESpecial Histochemical StainStains mucopolysaccharides in tissue and cell walls of cryptococcus24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
MUM1ImmunohistochemistryExpressed in Hodgkin's lymphoma and other lymphomas24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
MYELOPEROXIDASEImmunohistochemistryA marker of myeloid and histiocytic cells24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
MYOGLOBINImmunohistochemistryExpressed in skeletal and cardiac muscle, but not in smooth muscle24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
NKX3.1ImmunohistochemistryExpressed in prostate carcinoma24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
P16ImmunohistochemistrySurrogate marker of HPV infection, helpful in differentiating nevi from melanoma24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
P40ImmunohistochemistryNuclear expression in squamous, urothelial, myoepithelial/ basal cell differentiation24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
P504S (racemase)ImmunohistochemistryExpressed in prostate cancer, other carcinomas, and high grade dysplasia24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
P53Immunohistochemistryp53 tumor suppressor gene24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
P63ImmunohistochemistryMyoepithelial/ basal, and squamous differentiation24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
PANKERATIN (AE1/AE3)ImmunohistochemistryUsed to identify epithelial tumors and differentiate hepatoma vs. adenocarcinoma.24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
PAS-F (GREEN COUNTERSTAIN)Special Histochemical StainIdentifies fungal organisms24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
PAX8ImmunohistochemistryExpressed in thyroid, kidney, female reproductive tract carcinomas24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
PERIODIC ACID SCHIFF (PAS)Special Histochemical StainDetects polysaccharides (glycogen, glycoproteins, mucin) and fungal organisms24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
PERIODIC ACID SCHIFF WITH DIASTASE (PAS-D)Special Histochemical StainMucin, globules in alpha-1 antitrypsin deficiency, fungal organisms, digests glycogen24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
PERLS’ PRUSSIAN BLUE IRONSpecial Histochemical StainDetects ferric (Fe3+) iron in tissue24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
PHH3ImmunohistochemistryUsed as a marker for mitosis24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
PMS-2ImmunohistochemistryUsed to identify hereditary cancer syndromes and mismatch repair gene mutations24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
PRAMEImmunohistochemistryA molecular marker used in differentiating melanoma from nevus24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
Progesterone receptor (PR)ImmunohistochemistryIdentify PR receptor expression in breast cancer.24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
Prostate specific antibody (PSA)ImmunohistochemistryExpressed in prostatic tissue24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
RETICULINSpecial Histochemical StainStains reticulin fibers made up of type 3 collagen24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
S-100ImmunohistochemistryExpressed in schwannian, myoepithelial, and melanocytic cells24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
SAT B2ImmunohistochemistryUsed in identifying colorectal carcinomas, osetoblasts, and osteosarcoma.24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
SMOOTH MUSCLE ACTINImmunohistochemistryExpressed by smooth muscle, myoepithelial cells, and myofibroblasts24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
SOX-10ImmunohistochemistryA sensitive nuclear melanocytic marker, also expressed in schwannian and myoepithelial cells24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
SPIROCHETEImmunohistochemistryIdentifies spirochetes in cases of syphilis and spirochetosis24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
SYNAPTOPHYSINImmunohistochemistryA marker of neuroendocrine differentiation24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
TRICHROMESpecial Histochemical StainUsed to demonstrate collagenous stroma24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
TTF-1ImmunohistochemistryExpressed in thyroid carcinomas and lung adenocarcinomas24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
TYROSINASEImmunohistochemistryExpressed in melanocytes24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
UROPLAKINImmunohistochemistryExpressed in urothelial tumors.24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
VARICELLA ZOSTERImmunohistochemistryDetects Varicella Zoster virus24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
Verhoeff’s Van Gieson (VVG)Special Histochemical StainStains elastic fibers in tissue sections24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
VIMENTINImmunohistochemistryExpressed by cells of mesenchymal origin24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry
WARTHIN-STARRYSpecial Histochemical StainStains Heliobacter sp., spirochetes and other microorganisms in tissues24 Hours*Paraffin block or unstained sections on charged slidesspecial-stains
Wilms tumor 1 (WT-1)ImmunohistochemistryExpressed in leukemia and solid tumors such as mesothelioma, and ovarian carcinoma24 to 48 Hours*Paraffin block or unstained sections on charged slidesimmunohistochemistry